Tumor-induced osteomalacia localized and excised after pregnancy
نویسندگان
چکیده
منابع مشابه
Tumor-induced osteomalacia.
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic form of renal phosphate wasting that results in severe hypophosphatemia, a defect in vitamin D metabolism, and osteomalacia. This debilitating disorder is illustrated by the clinical presentation of a 55-year-old woman with progressive fatigue, weakness, and muscle and bone pain with fractures. After a protracted clinical course and exte...
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Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome clinically characterized by bone pain, fractures and muscle weakness. It is caused by tumoral overproduction of fibroblast growth factor 23 (FGF23) that acts primarily at the proximal renal tubule, decreasing phosphate reabsorption and 1α-hydroxylation of 25 hydroxyvitamin D, thus producing hypophosphatemia and osteomalacia. Les...
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Tumor-induced osteomalacia (TIO) is a rare paraneoplastic disorder in which a neoplasm causes systemic bone demineralization. Most cases are benign, but malignant neoplasms have been reported. The prognosis is good if diagnosis is made early and treatment is adequate. We present the case of a previously healthy 40-year-old man who presented with low back pain for the previous year. The initial ...
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A 77-year-old man was suspected of having tumor-induced osteomalacia (TIO) because of hypophosphatemia (1.9 mg/dL) and elevated serum fibroblast growth factor 23 (FGF23) level (186.9 pg/mL). We detected a tumor in his left parotid gland, and the FGF23 level in the left external jugular vein indicated that the tumor overproduced FGF23. After the removal of the tumor, the serum FGF23 level rapidl...
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The association of osteomalacia with neurofibromatosis is a very rare entity. Here a 34 year old man, a known case of neurofibromatosis, is reported who presented with bone pain, hypophosphatemia, rena] phosphorus wasting, multiple Looser's pseudofractures, and low bone density. Treatment with high dose calcitriol and phosphate resulted in temporary treatment. Permanent cure was achieved a...
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ژورنال
عنوان ژورنال: AACE Clinical Case Reports
سال: 2021
ISSN: 2376-0605
DOI: 10.1016/j.aace.2021.06.008